Let the Data Flood Begin: Full Scan PK at MSACL

Development of a Small Volume Sampling Technique and LC-MS Orbitrap Assay for Pediatric Pharmacokinetic Studies of Fentanyl and its Metabolites (Uwe Christians, Clinical Research and Development, Department of Anesthesiology, University of Colorado Denver).  In this talk, Uwe showed the sensitivity and selectivity of using full scan data for PK type data.  Because you don’t have to select a specific transition, you get a full spectrum during each aquisition which can be interrogated later for metabolites that may not have been part of an initial hypothesis.  Kevin Bateman from Merck showed this type of experiement a few years ago at ASMS, but it appears that the Oritrap can really do this experiment.  This blows up the amount of data collected in a PK study by at least an order of magnitude, and it increases the value of data stored for long term access by at least as much.